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Environmental toxins is one of the 9 variables in your health and longevity we assess. The other 8 variables are genetic variants, trauma, what you eat, what you drink, how you rest, how you exercise, what/how you braethe, and what you think. Environmental toxins are a real threat to our health and so often overlooked by most doctors as a potential causation for the symptoms the patient are presenting with.

Some 80, 000 chemicals have been introduced into our environment since WWII.  The vast majority of these chemicals are not even monitored by the EPA (Environmenatl Protection Agency). The source of these toxins is through the food chain from the food we eat, the water we drink, and the air we breathe. ADHD, autism, cardiovascular disease, diabetes, auto-immune disease, hypothyroidism, and sex hormone imbalances/deficiencies have all been linked to environmental toxins.

An approach that evaluates the body burden of potential environmental toxins coupled with supplementing essential micronutrients that chelate specific toxins and detoxify them from the body and eliminating the source of these pollutants with air and wate purification systems and consuming organic foods produces positive changes in the health of individuals suffering from environmental toxins.

The following are excerpts from Is Your Environment Stressing You Out? How To Pro-Actively Protect Yourself From Environmental Toxins by Kely Miller DC NMD FASA FBAARM CFMP.

The concept I would like you to grasp here is that for many of us our environment is causing a never ending fight/flight response for many. As these stressors accumulate through the aging process we lose the ability to maintain homeostasis. It is no wonder so many are so sick. Specifically, the water we are drinking, showering in, and bathing and swimming in, the air we are breathing at home and/or work, and much of the food we are eating is full of toxins that are relentlessly attacking us and breaking down our immune and detoxification systems. This prolonged fight/flight response leads to inflammation with subsequent hormone depletion, micronutrient depletion, sticky blood, endothelial vascular damage, small intestine hyperpermeability (leaky gut), and mitochondrial dysfunction. We need to eliminate or at least greatly reduce the body burden of heavy metals, pesticides, herbicides, petroleum byproducts, PBAs, PCBs, and the like in order to get healthier.

            This book is the third in a seven book series called Health Restoration. This book reveals potential causes for chronic illness and diseases that most individuals and doctors have not considered. For example, mercury toxicity can cause two common health problems - hypertension and hypothyroidism. Assessing the hypertensive or hypothyroid patient for mercury toxicity is not even in the thought process of most physicians..............

Environmental Testing:

MRT (MEDIATOR RELEASE TESTING) FOOD/CHEMICAL ALLERGY/SENSITIVITY 

Is your food making you sick? Do you suffer from chronic fatigue, fibromyalgia, migraines, irritable bowel syndrome, heartburn/GERD, chronic sinusitis, fibromyalgia, arthritis, chronic joint pain, chronic sinus problems, insomnia, weight imbalances, autism/ADD, chronic diarrhea, skin eruptions, muscle pain?

Are you suffering from a stubborn health problem that won't go away no matter what you do? Or perhaps the medications or treatments you're taking aren't actually getting at the root cause of your illness- but you want something that will? If you feel this way, or know someone that does, consider some important facts:

Medical Research has shown that sensitivities to foods and food-chemicals can be involved in a wide variety of painful symptoms and chronic health problems.

If foods and additives in your diet are causing your illness, whatever medications you are taking will ultimately fail because they only mask the symptoms. They don't treat the underlying cause of the symptoms. And as it is too often the case, many medications have side effects that can lead to other health problems.

If food sensitivities are causing your illness and you don't properly address them, you could easily end up suffering for many years, spending thousands of dollars and lost time, productivity, and quality of life for treatments that will never work the way you want.

The solution for illness caused by food sensitivity.....

With the patented blood test called MRT (Mediator Release Test) you can account for both Type 3 and Type 4 pathways. MRT also identifies reactions to food chemicals. This is translated into faster and more complete relief for those who test with MRT. In fact, independent studies confirm MRT is the most accurate and most comprehensive blood test available for food and food-chemical reactions.

A simple blood test could hold the answer to your chronic health problems. Call today for a consultation at our Temple Terrace, Florida office.

HEAVY METAL TESTING

            Heavy metal poisoning from cadmium, lead, arsenic, aluminum, and others, especially mercury may be more prevalent than anyone suspected. To my knowledge there have not been multiple studies on a general population to determine if heavy metal toxicities exist in a large percentage of the population. However, in 2007, one thousand people gathered for a four day health seminar related to mercury testing. Of the one thousand attendees, 680 men and women from the ages of eighteen to seventy who lived throughout the U. S. and Canada were tested. An alarming ninety five percent of the people tested with body mercury levels in the ‘Elevated’ or ‘Very Elevated’ reference range, and just five percent tested in the ‘Green’, or 0 reference range.

            Cadmium and lead can be found in automobile and industrial vapors, and lead may come from our fillings, and lead contamination can occur from lead-based paints.  Aluminum toxicity can occur secondary to exposure to aluminum cookware and cans. Arsenic is frequently found in well water. Of all these, mercury seems to be most prevalent. In 1991, the World Health Organization, conformed that, “Mercury contained in dental amalgam is the greatest source of mercury vapor in non-idustrialized settings exposing the concerned population to mercury levels significantly exceeding those set for food and for air. But “silver” fillings are not the only source of mercury. Certain types and brands of the following common products also may contain mercury: fish, thermometers, button cell batteries, skin crèmes, vaccines, barometers, cosmetics, tattoos, thermostats, light-up sports shoes, disinfectants, and fluorescent light bulbs. Exposure to mercury can occur in a number of ways.  On may come in contact with mercury or its fumes from broken thermometer, and other spills in the home, school, or workplace, or breathe in airborne mercury from a coal burning power plant, mining operations, or other industrial sources. Thousands of people work in an occupation that uses mercury, such as a dental office or manufacturing plant. Millions are exposed daily by eating fish that have been contaminated with methyl mercury.  In general, the larger the fish, the more susceptible it is to mercury contamination. Different regions around the world have different fish on the “consumer beware” list, but a few of the most at risk are shark, swordfish, grouper, tuna, Chilean Sea Bass, marlin, tilefish, and farmed salmon. (Do not eat farmed salmon because of the extreme high levels of arachadonic acid, which causes inflammation.)

            There are a number of chelating agents out there to determine heavy metal toxicity, two of which are DMPS and DMSA. For mercury, cadmium, and lead, we like DMPS because approximately fifty percent of oral administered DMPS is rapidly absorbed in the gastrointestinal tract and is excreted by the kidneys. The highest urinary concentration occurs two to three hours after oral administration. Neither DPMS nor its metabolites are detected twelve hours after administration in animal studies. DMPS is the most productive agent for the provoked urine toxic element, particularly when mercury is of concern. Only about twenty percent of the DMSA is absorbed into the gastrointestinal tract. Studies performed at Doctor’s Data Laboratory indicate that oral DMSA (30mg/kg/day) for one to three days only yields about one-fifth to one-tenth of the amount of mercury in the urine as a single dose of DMPS. Therefore, many physicians prefer DMPS instead of DMSA for the initial challenge and subsequent detoxifying agent for mercury. For heavy metals other than mercury, cadmium, or lead, we prefer liposomal EDTA for detoxification.

            What does mercury do to the body? Mercury is a toxic heavy metal that is not found naturally in the body. In fact, it is a poison that can cause long-lasting damage to the body. According to the World Health Organization.”Recent studies suggest that mercury may not have a thresh-hold level in which some adverse effects do not occur.” The following are a few health issues that have been linked to mercury exposure: Emotions - rage and anger, depression, mood swings, anxiety. Reproductive System - infertility, impotency, birth defects. Hormones and Sexuality - low thyroid function, low libido, erectile dysfunction. Heart - arrhythmia, shortness of breath, angina, heart failure. Brain - “brain fog”, dementia, Alzheimer’s, “senior moments”. General Health - fatigue, unexplainable weight gain, cold extremities, headaches. Immune System - recurring infection, autoimmune disease, rashes, allergies/asthma. Nervous System - numbness, tremors, neuropathy, vision/hearing problems, MS or ALS.

            The detoxification length is dependent upon test levels and individual response to treatment. However, in the outcome of one group of 147 individuals using DMPS for mercury toxicity, sixty three percent or ninety three out of one hundred forty four obtained an elimination average of sixty nine percent in thirty to sixty days.

 GPL-TOX:  Toxic Non-Metal Chemical Profile

            Every day, we are exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides, packaged foods, household products, and environmental pollution.  As we have become more exposed to chemical-laden products and to toxic chemicals in food, air, and water, we have been confronted with an accelerating rate of chronic illnesses like cancer, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D, autoimmune disorders, Parkinson’s disease, and Alzheimer’s disease. 

            Because exposure to environmental pollutants has been linked to many chronic diseases, The Great Plains Laboratory has created GPL-TOX, a toxic non-metal chemical profile that screens for the presence of 172 different toxic chemicals including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile, and more.  This is one of the common panels I run to evaluate the body burden of environmental toxins. This profile also includes Tiglylglycine (TG), a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA.  These mutations can be caused by exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

            There are many advantages to using the GP-TOX profile. Some of these are the following:

  • GPL-TOX screens for 172 different environmental pollutants using 18 different metabolites, all from a single urine sample.
  • GPL-TOX uses the power of advanced mass spectrometry (MS/MS), which is necessary to detect lower levels of certain genetic, mitochondrial, and toxic chemical markers that conventional mass spectrometry often misses.
  • GPL-TOX also includes Tiglylglycine, a marker for mitochondrial damage, which is often seen in chronic toxic chemical exposure.
  • GPL-TOX pairs perfectly with their Organic Acids Test (OAT) and  Glyphosate Test in the Enviro-TOX Panel.  This panel offers comprehensive testing to assess exposure to common environmental toxins and the damage that can be caused by this exposure, all at a great value, and all from one urine sample.

            The following groups of chemicals are testing in the GPL-TOX panel.

Phthalates
            Perhaps the most widespread group of toxic chemicals found in our environment. Phthalates are commonly found in after shave lotions, aspirin, cosmetics, detergents, foods microwaved with plastic covers, oral pharmaceutical drugs, intravenous products prepared in plastic bags, hair sprays, insecticides, insect repellents, nail polish, nail polish remover, skin care products, adhesives, explosives, lacquer, janitorial products, perfumes, paper coatings, printing inks, safety glass, and varnishes. Phthalates have been implicated in reproductive damage, depressed leukocyte function, and cancer. Phthalates have also been found to impede blood coagulation, lower testosterone, and alter sexual development in children. Low levels of phthalates can feminize the male brain of the fetus, while high levels can hyper-masculinize the developing male brain.

Vinyl Chloride
            Vinyl chloride is an intermediate in the synthesis of several commercial chemicals, including polyvinyl chloride (PVC). Exposure to vinyl chloride may cause central nervous system depression, nausea, headache, dizziness, liver damage, degenerative bone changes, thrombocytopenia, enlargement of the spleen, and death.

Benzene
            Benzene is an organic solvent that is widespread in the environment. Benzene is a by-product of all sources of combustion, including cigarette smoke, and is released by outgassing from synthetic materials, and is a pollutant released by numerous industrial processes. Benzene is an extremely toxic chemical that is mutagenic and carcinogenic. High exposures to benzene cause symptoms of nausea, vomiting, dizziness, lack of coordination, central nervous system depression, and death. It can also cause hematological abnormalities.

Pyrethrins
            Pyrethrins are widely used as insecticides. Exposure during pregnancy doubles the likelihood of autism. Pyrethrins may affect neurological development, disrupt hormones, induce cancer, and suppress the immune system.

Xylenes
            Xylenes (dimethylbenzenes) are solvents found not only in common products such as paints, lacquers, pesticides, cleaning fluids, fuel and exhaust fumes, but also in perfumes and insect repellents. Xylenes are oxidized in the liver and bound to glycine before eliminated in urine. High xylene levels may be due to the use of certain perfumes and insect repellents. High exposures to xylene create an increase in oxidative stress, causing symptoms such as nausea, vomiting, dizziness, central nervous system depression, and death. Occupational exposure is often found in pathology laboratories where xylene is used for tissue processing.

Styrene
            Styrene is used in the manufacturing of plastics, in building materials, and is found in car exhaust fumes. Polystyrene and its copolymers are widely used as food-packaging materials. The ability of styrene monomer to leach from polystyrene packaging to food has been reported. Occupational exposure due to inhalation of large amounts of styrene adversely impacts the central nervous system, causes concentration problems, muscle weakness, tiredness and nausea, and irritates the mucous membranes of the eyes, nose, and throat.

Organophosphates
            Organophosphates are one of the most toxic groups of substances used throughout the world. They are often used as biochemical weapons and terrorist agents, but are most commonly used in pesticide formulations. Organophospates are inhibitors of cholinesterase enzymes, leading to overstimulation of nerve cells, causing sweating, salivation, diarrhea, abnormal behavior, including aggression and depression. Children exposed to organophosphates have more than twice the risk of developing pervasive developmental disorder (PDD), an autism spectrum disorder. A study done in the San Francisco Bay area found that in California agricultural areas, children born to mothers living within 500 meters of fields where organochlorine pesticides were used were more than 6 times more likely to develop autism than children whose mothers did not live near such fields. ASD risk increased with the poundage of organochlorines applied and decreased with distance from field sites. Maternal organophosphate exposure has been associated with various adverse outcomes including having shorter pregnancies and children with impaired reflexes.

MTBE and ETBE
            MTBE and ETBE are gasoline additives used to improve octane ratings. Exposure to these compounds is most likely due to groundwater contamination, and inhalation or skin exposure to gasoline or its vapors and exhaust fumes. MTBE has been demonstrated to cause hepatic, kidney, and central nervous system toxicity, peripheral neurotoxicity, and cancer in animals. Since the metabolites of these compounds are the same, ETBE may be similarly toxic.

2, 4-Dicholorophenoxyacetic (2,4-D)
            A very common herbicide that was a part of Agent Orange, used by the United States during the Vietnam War to increase visibility for war planes, by destroying plant undergrowth and crops. It is most commonly used in agriculture on genetically modified foods, and as a weed killer for lawns. Exposure to 2, 4-D via skin or oral ingestion is associated with neuritis, weakness, nausea, abdominal pain, headache, dizziness, peripheral neuropathy, stupor, seizures, brain damage, and impaired reflexes. 2, 4-D is a known endocrine disruptor, and can block hormone distribution and cause glandular breakdown.

Diphenyl Phosphate
            This is a metabolite of the organophosphate flame retardant triphenyl phosphate (TPHP), which is used in plastics, electronic equipment, nail polish, and resins.  TPHP can cause endocrine disruption.  Studies have also linked TPHP to reproductive and developmental problems. 

Acrylamide
            Acrylamide can polymerize to form polyacrylamide.  Polyacrylamide is used in many industrial processes such as plastics, food packaging, cosmetics, nail polish, dyes, and treatment of drinking water.  Food and cigarette smoke are also two major sources of exposure.  Acrylamide has been found in foods like potato chips, French fries, and many others such as asparagus, potatoes, legumes, nuts, seeds, beef, eggs, and fish.  Asparagine, which is found in these foods can produce acrylamide when cooked at high temperature in the presence of sugars.  High levels of acrylamide can elevate a patient’s risk of cancer.  In addition, acrylamide is known to cause neurological damage.

Perchlorate
            This chemical is used in the production of rocket fuel, missiles, fireworks, flares, explosives, fertilizers, and bleach.  Studies show that perchlorate is often found in water supplies.  Many food sources are also contaminated with perchlorate.  Perchlorate can disrupt the thyroid’s ability to produce hormones.  The EPA has also labeled perchlorate a likely human carcinogen.  Patients that are high in perchlorate can use a reverse osmosis water treatment system to remove the chemical from their water supply.

1,3 Butadiene 
            This is a chemical made from the processing of petroleum.  It is often a colorless gas with a mild gasoline-like odor.  Most of this chemical is used in the production of synthetic rubber.  1,3 Butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease.  Individuals that come into contact with rubber, such as car tires, could absorb 1,3 Butadiene through the skin.  The increased use of old tires in the production of crumb rubber playgrounds and athletic fields is quite troubling because children and athletes may be exposed to toxic chemicals this way.

Propylene Oxide
            This chemical is used in the production of plastics and is used as a fumigant.   Propylene oxide is used to make polyester resins for textile and construction industries.  It is also used in the preparation of lubricants, surfactants, and oil demulsifiers.  It has also been used as a food additive, an herbicide, a microbicide, an insecticide, a fungicide, and a miticide.  Propylene oxide is a probable human carcinogen. 

1-Bromopropane (1-BP)
            1-Bromopropane is an organic solvent used for metal cleaning, foam gluing, and dry cleaning.  Studies have shown that 1-BP is a neurotoxin as well as a reproductive toxin.  Research indicates that exposure to 1-BP can cause sensory and motor deficits.  Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system.  Acute exposure can lead to headaches.

Ethylene Oxide
            Ethylene oxide is used in many different industries including agrochemicals detergents, pharmaceuticals, and personal care products.  Ethylene oxide is also used as a sterilizing agent on rubber, plastics, and electronics.  Chronic exposure to ethylene oxide has been determined to be mutagenic to humans.  Multiple agencies have reported it as a carcinogen.  Studies of people exposed to ethylene oxide show an increased incidence of breast cancer and leukemia.  Caution is needed with ethylene oxide because it is odorless at toxic levels.

Acrylonitrile
            Acrylonitrile is a colorless liquid with a pungent odor.  It is used in the production of acrylic fibers, resins, and rubber.  Use of any of these products could lead to exposure to acrylonitrile.  Smoking tobacco and cigarettes is another potential exposure.  Exposure to acrylonitrile can lead to headaches, nausea, dizziness, fatigue, and chest pains.  The European Union has classified acrylonitrile as a carcinogen.

            The following are a list of conditions in alphabetic order that I recommend the GPL-TOX panel for:

  • Alzheimer's Disease
  • Amyotrophic Lateral Sclerosis (ALS)
  • Anorexia Nervosa
  • Anxiety Disorder
  • Apraxia
  • Arthritis
  • Asthma
  • Attention deficit (ADD)
  • Attention deficit with hyperactivity (ADHD)
  • Autism
  • Autoimmune disorders
  • Bipolar disorder
  • Cancer
  • Cerebral palsy
  • Chronic fatigue syndrome
  • Crohn's disease
  • Depression
  • Developmental disorder
  • Down Syndrome
  • Epilepsy
  • Failure to thrive
  • Fibromyalgia
  • Genetic diseases
  • Irritable bowel syndrome
  • Learning disability
  • Mitochondria disorder
  • Multiple sclerosis
  • Obsessive compulsive disorder (OCD)
  • Occupational exposures
  • Parkinson's disease
  • Peripheral neuropathy
  • Schizophrenia
  • Seizure disorders
  • Systemic lupus erythematosus
  • Tic disorders
  • Tourette syndrome
  • Ulcerative colitis

            The seventh sequela of chronic stress and inflammation is mitochondrial DNA dysfunction. The GPL-TOX profile tests for Tiglylglycine (TG), one of the most specific markers for mitochondrial disorders resulting from mutations of mitochondrial DNA. These mutations can result from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies. Mitochondria are important in all cells in the body, but are especially important to organs that utilize large amounts of energy, such as the muscles, heart, and brain. The mitochondria also have several other important functions in the cell, including steroid synthesis, calcium regulation, free radical production, and the induction of apoptosis or programmed cell death, all of which are involved in the pathogenesis of numerous disorders. The marker used in the GPL-TOX profile indicates mitochondrial dysfunction by monitoring a metabolite that is elevated in mitochondrial deficiency of cofactors such as NAD+, flavin-containing coenzymes, and Coenzyme Q10. Disorders associated with mitochondrial dysfunction include autism, Parkinson's disease, and cancer.

            There are multiple metabolites that are measured that are produced by a body burden of environmental toxins. Some of these are the following:

2-Methylhippuric Acid (2MHA), 3-Methylhippuric Acid (3MHA), 4-Methylhippuric Acid (4MHA)
            These are metabolites of xylenes, solvents found in paints, lacquers, cleaning agents, pesticides, and gasoline. Exposure to xylenes generates methylhippuric acid isomers. Avoid/reduce exposure to these substances.

N-acetyl phenyl cysteine (NAP)
            NAP is a metabolite of benzene. Benzene is a solvent that is widespread in the environment. It is found in cigarette smoke and gasoline, and is a byproduct of all types of combustion, including motor vehicle exhaust. Treatment consists of removing sources of exposure.

Phenylglyoxylic Acid (PGO)
            Exposure to environmental styrene may slightly increase phenylglyoxylic and mandelic acid. Reduce exposure by eliminating the use of plastic and styrofoam containers for cooking, reheating, eating or drinking. Elimination of styrene can be accelerated by supplementing with glutathione and N-acetyl cysteine (NAC).

2-Hydroxyisobutyric Acid (2HIB)
            2-Hydroxyisobutyric acid is formed endogenously as a product of branched-chain amino acid degradation and ketogenesis. This compound is also the major metabolite of gasoline octane enhancers such as MTBE and ETBE. Elevated levels indicate environmental exposure and very high values have been reported in genetic disorders.

Monoethyl Phthalate (MEP)
            MEP from diethyl phthalate is the most abundant phthalate metabolite found in urine. Diethyl phthalate is used in plastic products. Elevated values indicate exposure from various possible sources. Elimination of phthalates may be accelerated by sauna treatment.

Dimethylphosphate (DMP) & Diethylphosphate (DEP)
            DMP and DEP are major metabolites of many organophosphate pesticides. Reduce exposure by eating organic foods and avoiding use of pesticides in your home or garden. Living near agricultural areas or golf courses and areas regularly sprayed with pesticides will increase exposure. Elimination of organophosphates can be accelerated by sauna treatment.

3-Phenoxybenzoic Acid (3PBA)
            3-Phenoxybenzoic acid is a metabolite of pyrethroid insecticides. Elimination can be accelerated by sauna treatment.

2,4-Dichlorophenoxyacetic Acid (2,4-D)
            2,4-D was an ingredient in Agent Orange, and is most commonly used in agriculture of genetically modified foods, and as a weed killer for lawns. Reduce exposure by eating organic foods and avoiding use of pesticides in your home or garden.

Tiglylglycine (TG)
            TG is a marker for mitochondrial dysfunction. Mutations of mitochondria DNA may result from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

N-acetyl-S-(2-carbamoylethyl)-cysteine
            NAE is a metabolite of acrylamide, which is detoxified through a two-step process.  First acrylamide is metabolized by the cytochrome P450s.  Second it is conjugated to glutathione in order to make it more water soluble.  Acrylamide is used in many industrial processes such as plastics, food packaging, cosmetics, nail polish, dyes, and treatment of drinking water.  High levels of acrylamide can elevate a patient’s risk of cancer and cause neurological damage.  Supplementation with glutathione can assist in the elimination of this compound. 

Diphenyl Phosphate
            This is a metabolite of the organophosphate flame retardant triphenyl phosphate (TPHP), which is used in plastics, electronic equipment, nail polish, and resins.  TPHP can cause endocrine disruption.  Studies have also linked TPHP to reproductive and developmental problems.

Perchlorate
            Perchlorate is used in the production of rocket fuel, missiles, fireworks, flares, explosives, fertilizers, and bleach.  Studies show that perchlorate is often found to contaminate water supplies and food sources.  It can disrupt the thyroid’s ability to produce hormones.  The EPA has also labeled perchlorate a likely human carcinogen.  Patients that are high in perchlorate can use a reverse osmosis water treatment system or the  Mutipure Aquaperform solid carbon filter to remove perchlorate.

N-Acetyl (3,4-Dihydroxybutyl) Cysteine (NABD)
            NADB is a metabolite of 1,3 butadiene, which is evident of exposure to synthetic rubber such as tires.  1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease.  Individuals that come into contact with rubber, such as car tires, could absorb 1,3 butadiene through the skin.

N-Acetyl (2,Hydroxypropl) Cysteine (NAHP)
            NAHP is a metabolite of propylene oxide which is used in the production of plastics and as a fumigant.  It is also used in the preparation of lubricants, surfactants, and oil demulsifiers and as a food additive, an herbicide, a microbicide, an insecticide, a fungicide, and a miticide.  Propylene oxide is a probable human carcinogen.   

N-Acetyl (Propyl) Cysteine (NAPR)
            NAPR is a metabolite of 1-bromopropane.  Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system.  Acute exposure can lead to headaches.

2-Hydroxyethyl Mercapturic Acid (HEMA)
            HEMA is a metabolite of ethylene oxide, which is used in the production of agrochemicals, detergents, pharmaceuticals, and personal care products.  Chronic exposure to ethylene oxide has been determined to be mutagenic to humans.    HEMA is also a metabolite of vinyl chloride and halopropane, which are used in many commercial chemical processes such as foam glueing, dry cleaning, and in the production of solvents.  Supplementation with glutathione should assist in the detoxification process of these chemicals.

N-Acetyl (2-Cyanoethyl) Cysteine (NACE)
            NACE is a metabolite of acrylonitrile, which is used in the production of acrylic fibers, resins, and rubber.  Acrylonitrile is metabolized by the cytochrome P450s and then conjugated to glutathione.  Supplementation with glutathione should assist in the detoxification of acrylonitrile.

            There are several common considerations for positive findings in the GPL-TOX panel. If you or a patient has had a GPL-TOX profile and/or a Glyphosate test run and found moderate-high levels of any compounds, there are things you can do to help your body eliminate the toxins and to prevent future exposures.  The first steps to reducing the amount of toxins presently in the body are to switch to eating only organic food and drinking water that has common toxins, including pesticides filtered out.  Most conventional food crops are exposed to larger and larger doses of pesticides and herbicides, and by switching to organic you will prevent exposure to hundreds of these toxicants.  Many of these chemicals have also contaminated our water supplies.  Installing a high-quality reverse osmosis water filtration system or solid carbon filter such as Multipure in the home that eliminates them is important to do and there are several options available. More information will be made available on the chapter on Water Pollution Solutions.

            The next step to avoiding future exposures is to change the products you use on a daily basis – from food and beverage containers to beauty and cleaning products.  Instead of using plastic water bottles and food containers, switch to glass or metal.  Never microwave food in plastic or styrofoam containers and do not drink hot beverages from plastic or styrofoam cups.  Make sure your shampoo, soaps, lotions, and other beauty products are free of phthalates.  Use cleaning products made from natural green ingredients or make your own at home.  

            To eliminate toxins from the body, we highly recommend exercise and the use of saunas, especially infrared sauna therapy to rid many chemicals through sweat.  Infrared sauna is superior to conventional sauna because it reaches deeper into the body, increasing the circulation in the blood vessels, and causing the body to start to releasing many of the chemicals stored in body fat.  

            There are two supplements that are particularly useful in helping the body detoxify.  The first is glutathione, or its precursor N-acetyl cysteine.  Glutathione is one of the most common molecules used by the body to eliminate toxic chemicals.  If you are constantly exposed to toxicants your stores of glutathione could be depleted.  The second supplement is vitamin B3 (niacin).  Some may not enjoy the flushing that can happen when taking niacin, however, this flushing is from the blood vessels dilating, which is useful in the detoxification process.  If sensitive to the flushing, start with the lowest recommended dose and work up from there.

For more information on detoxification, refer to the Summary chapter at the end of the book.

For more information about testing procedures and cost, contact our office at 813-985-5190.

Kelly Miller DC NMD FASA FBAARM CFDMP